Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency
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چکیده
منابع مشابه
Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.
Myeloperoxidase (MPO), present in the azurophilic granules of polymorphonuclear leukocytes, is a myeloid enzyme whose synthesis is restricted to promyelocytes. Complete hereditary MPO deficiency affects 1 in 2,000 to 4,000 individuals; however, the genetic cause of this defect is unclear. We have determined the molecular basis of MPO deficiency in one individual (SQ). Granulocytes of SQ had no ...
متن کاملMyeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers.
The myeloperoxidase (MPO) -463G-->A genetic polymorphism is associated with a reduced risk for lung cancer, but the underlying mechanism is not yet elucidated. Therefore, the impact of this polymorphism on MPO activity and lipophilic DNA adducts was studied in respectively bronchoalveolar lavage (BAL) fluid and cells, from 106 smoking Caucasian lung patients. MPO activity was determined spectro...
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OBJECTIVES Many studies have evaluated the ways in which sleep disturbances may influence inflammation and the possible links of this effect to cardiovascular risk. Our objective was to investigate the effects of chronic sleep restriction and recovery on several blood cardiovascular biomarkers. METHODS AND RESULTS Nine healthy male non-smokers, aged 22-29 years, were admitted to the Sleep Lab...
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Name of Gene Marker. MPO, myeloperoxidase. Source and Description of Primers. Primers (set A) were designed based on human (Genbank Accession no. D14466) and mouse (Genbank Accession no. X15313) MPO exon 9 and 10 sequences available in the Genbank database. Using porcine genomic DNA as template in the PCR, these primers amplified a 1-kb fragment. Set B primers were designed based on pig DNA seq...
متن کاملHereditary myeloperoxidase deficiency.
Subjects with neutrophil myeloperoxidase (MPO) deficiency have been rarely reported. In part this may be due to the lack of a simple screening technique that would detect them. With the routine use of a cytochemical leukocyte differential counter that employs MPO stains, over a 40-mo a period 8 unrelated probands with partial MPO-deficiency and one with complete deficiency were identified. Fami...
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ژورنال
عنوان ژورنال: Blood
سال: 1994
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v83.7.1935.1935